In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (+-)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
Provides an authoritative source of practical information on stereochemistry and its impact on drug development. Unlike other books which focus on synthesis, this work explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. It specifically addresses how the body metabolizes chiral molecules; the varying effects of different chiral molecules; and provides detailed evaluations of current seperation techniques. Includes regulatory information.
Preface; Stereoselective Methods Towards the Synthesis of Iminosugars; Stereochemical Studies in Insect Chemistry: Synthesis and Properties of Chiral Rsesolving Agents; Stereochemistry of Aflastatin A and Blasticidin A: Application of J-based, Acetonide and NMR Database Methods.; Syntheses, Structure and Electronic Properties of Assemblies of Diastereomers of Nickel (II) Complexes with Tetracyanometalates [M(CN)4]2 (M=Ni, Pd, and Pt); (4R*, 5R*) - 4 - Benzoylamino-5-Phenyl-3-Pyrazolidinone - A Useful Building Block in the Synthesis of Functionalised Pyrazoles; Stereochemical aspects of Interaction Between some Monosaccharides and L-Alpha-Amino Acids in Aqueous Solutions; Challenges in Carbohydrate Chemistry: A Survey of Modern Approaches for L-Hexose Stereoselective Synthesis; Index.